What is SPRIX®?

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SPRIX® (ketorolac tromethamine) is indicated in adult patients for the short term (up to 5 days) management of moderate to
moderately severe pain that requires analgesia at the opioid level.

Limitations of Use

  • Sprix is not for use in pediatric patients less than 2 years of age.

SPRIX® (ketorolac tromethamine) is:

  • Prescribed for adult patients who require opioid-strength pain relief for up to 5 days
  • The first nonsteroidal anti-inflammatory drug (NSAID) pain-relieving nasal spray
  • A medicine that contains a potent pain reliever

SPRIX is not:

  • An opioid narcotic pill
  • A patch or injection
  • A controlled substance

SPRIX Nasal Spray can be used for short-term treatment of moderate to severe pain for up to 5 days in adult patients who require opioid-strength pain relief.

SPRIX® (ketorolac tromethamine) comes in a carton with 5 pre-filled bottles

SPRIX is delivered through a nasal spray. Each carton contains 5 bottles, with each bottle containing 8 precisely metered doses.

SPRIX is intended for use:

Every 6-8 hours*

Up to 4 times a day

For up to 5 days, as needed

*For adult patients < 65 years of age,
≥ 110 lbs, and normal kidney function, the recommended dose is 1 spray in each nostril every 6-8 hours up to 4 times a day. For adult patients ≥ 65 years of age, renally impaired patients, and adult patients < 110 lbs, the recommended dose is 1 spray in 1 nostril every 6-8 hours up to 4 times per day.

How should I store SPRIX?

  • Store unopened SPRIX bottles between 36°F to 46°F (2°C to 8°C)
  • Keep opened bottles of SPRIX at room temperature
  • Keep SPRIX out of direct sunlight
  • Do not freeze SPRIX
  • SPRIX does not contain a preservative. Throw away each SPRIX bottle within 24 hours of taking your first dose, even if the bottle still contains unused medicine

Instructions for use of sprix® (ketorolac tromethamine) nasal spray

SPRIX is for use in the nose only. Do not breathe in (inhale) SPRIX.

Before you use SPRIX for the first time, you will need to prime the bottle. Hold the finger flange with your fingers (see Figure A), and remove the clear plastic cover with your opposite hand. Keep the clear plastic cover for later. Remove and throw away the blue plastic safety clip.

If the clear plastic cover is improperly removed, the tip of the bottle may be pulled off of the glass vial. If this happens, place the tip back onto the glass vial by lining it up carefully and gently pushing it back on until it is back in the correct position (see Figure B). The SPRIX bottle should work properly again.

Hold the SPRIX bottle upright at arm’s length away from you with your index finger on top of the finger flange and your thumb supporting the base (see Figure C).

Press down on the finger flange and release the pump 5 times. You may not see spray the first few times you press down. Now the pump is primed and ready to use. You do not need to prime the pump again if you use more doses from this bottle.

Blow your nose to clear your nostrils. Sit up straight or stand. Keep your head tilted downward toward your toes. Place the tip of the SPRIX bottle into your right nostril. Hold the SPRIX bottle upright and aim the tip toward the back of your nose (see Figure D).

Hold your breath and spray 1 time into your right nostril, pressing down on both sides of the finger flange (see Figure D). Breathe in gently through your mouth after you use SPRIX. You may also pinch your nose to help keep the medicine in your nose.

SPRIX is for use in the nose only. Do not breathe in (inhale) SPRIX.

If your healthcare provider has prescribed only 1 spray per dose for you, you have now finished your dose. However, if your healthcare provider has prescribed 2 sprays for you, repeat the above steps for your left nostril. Be sure to point the spray away from the center of your nose. Spray 1 time into your left nostril. When you are finished using SPRIX, put the clear plastic cover back on the SPRIX bottle.

SPRIX® Patient Use Video

how to use
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The information contained on this site is scientific in nature and was designed specifically for US Healthcare Professionals.