Bottle of SPRIX®

Using SPRIX®

SPRIX® (ketorolac tromethamine) Nasal Spray is the first and only intranasal NSAID.1 Each bottle contains 8 precisely metered doses of pain medicine.2

SPRIX® provides hospital-strength analgesia both inside and outside of the hospital. Clinical studies show that SPRIX® is an effective non-narcotic alternative for patients who require pain relief at the opioid level.3-5

SPRIX® is not a controlled substance. SPRIX® may be called into the pharmacy and is not subject to the additional prescribing requirements of controlled medications. SPRIX® prescriptions require no filing with Prescription Drug Monitoring Programs.2


  • Boyer KC, McDonald P, Zoetis T. A novel formulation of ketorolac tromethamine for intranasal administration: Preclinical safety evaluation. Int J Toxicol. 2010;29(5):467-478.
  • SPRIX® [package insert]. Shirley, NY: American Regent, Inc; 2011.
  • Brown C, Moodie J, Bisley E, Bynum L. Intranasal ketorolac for postoperative pain:
    a phase 3, double-blind, randomized study. Pain Med. 2009;10(6):1106-1114.
  • Singla N, Singla S, Minkowitz HS, Moodie J, Brown C. Intranasal ketorolac for acute postoperative pain. Curr Med Res Opin. 2010;26(8):1915-1923.
  • Grant GM, Mehlisch DR. Intranasal ketorolac for pain secondary to third molar impaction surgery: a randomized, double-blind, placebo-controlled trial. J Oral Maxillofac Surg. 2010;68(5):1025-1031.