Bottle of SPRIX®

SPRIX® – The First and Only Intranasal NSAID

SPRIX® (ketorolac tromethamine) Nasal Spray is the first and only intranasal NSAID, a novel form of ketorolac tromethamine, a proven pain reliever used in hospitals for more than 20 years.1 SPRIX® combines the strength of non-narcotic ketorolac2 with the advantages of a patient-administered nasal spray.

Potent Pain Relief

SPRIX® provides hospital-strength analgesia2 inside and outside the hospital for patients with moderate to moderately severe pain. SPRIX® also reduces the need for narcotics to manage pain.3


Ketorolac does not bind to opioid receptors. SPRIX® is not a controlled substance therefore prescriptions may be called into the pharmacy and do not require additional paperwork, and are not subject to filing with Prescription Drug Monitoring Programs.


  • Boyer KC, McDonald P, Zoetis T. A novel formulation of ketorolac tromethamine for intranasal administration: Preclinical safety evaluation. Int J Toxicol. 2010;29(5):467-478.
  • Moodie JE, Brown CR, Bisley EJ, Weber HU, Bynum L. The safety and analgesic efficacy of intranasal ketorolac in patients with postoperative pain. Anesth Analg. 2008;107(6):2025-2031.
  • Brown C, Moodie J, Bisley E, Bynum L. Intranasal ketorolac for postoperative pain: A phase 3, double-blind, randomized study. Pain Med. 2009;10(6):1106-1114.
  • SPRIX® [package insert]. Shirley, NY: American Regent, Inc; 2011.